{"id":1594,"date":"2022-02-17T10:24:53","date_gmt":"2022-02-17T09:24:53","guid":{"rendered":"https:\/\/www.urolon.com\/over-urolon\/mode-of-action\/"},"modified":"2026-06-10T21:48:22","modified_gmt":"2026-06-10T19:48:22","slug":"mode-of-action","status":"publish","type":"page","link":"https:\/\/www.urolon.com\/nl\/about-urolon\/mode-of-action\/","title":{"rendered":"Mode of action"},"content":{"rendered":"\n\t<section class=\"section\" id=\"section_180649985\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1340141115\">\n\n\t<div id=\"col-1538382324\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1846042648\">\n\t\t\t\t\t\t<div data-animate=\"fadeInDown\">\t\t<div class=\"img-inner dark\" style=\"margin:0px -15px -100px 0px;\">\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"1020\" src=\"https:\/\/www.urolon.com\/wp-content\/uploads\/2022\/02\/urolontekst.svg\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t\t\t\n<style>\n#image_1846042648 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-1538382324 > .col-inner {\n  margin: 0px 0px -369px 0px;\n}\n<\/style>\n\t<\/div>\n\n\t\n\n\t<div id=\"col-1101483125\" class=\"col medium-4 small-12 large-4\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_2109039981\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"1020\" src=\"https:\/\/www.urolon.com\/wp-content\/uploads\/2022\/02\/bal.svg\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_2109039981 {\n  width: 69%;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-1101483125 > .col-inner {\n  margin: 0px 0px -221px 0px;\n}\n<\/style>\n\t<\/div>\n\n\t\n<\/div>\n<div class=\"row align-middle align-center\"  id=\"row-2131156212\">\n\n\t<div id=\"col-1038275958\" class=\"col medium-10 small-11 large-7\"  data-animate=\"bounceInLeft\">\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div id=\"text-3856746574\" class=\"text\">\n\t\t\n<h1 class=\"title\">Mode of Action<\/sup><\/h1>\n\t\t\n<style>\n#text-3856746574 {\n  font-size: 2rem;\n}\n<\/style>\n\t<\/div>\n\t\n<p><a href=\"http:\/\/www.urolon.com\/healthcare-professionals\/about-urolon\/\"><strong>About Urolon\u2122<\/strong><\/a><\/p>\n\t<div class=\"ux-menu stack stack-col justify-start ux-menu--divider-solid\">\n\t\t\n\t<div class=\"ux-menu-link flex menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.urolon.com\/about-urolon\/what-is-urolon\/\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tWhat is Urolon\u2122\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.urolon.com\/about-urolon\/the-bioresorption-process\/\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tThe Bioresorption Process\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.urolon.com\/about-urolon\/mode-of-action\/\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tMode of action\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<div class=\"ux-menu-link flex menu-item\">\n\t\t<a class=\"ux-menu-link__link flex\" href=\"https:\/\/www.urolon.com\/about-urolon\/advantages-of-urolon\/\" >\n\t\t\t\t\t\t<span class=\"ux-menu-link__text\">\n\t\t\t\tAdvantages of Urolon\u2122\t\t\t<\/span>\n\t\t<\/a>\n\t<\/div>\n\t\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\n<style>\n#col-1038275958 > .col-inner {\n  margin: 0px -97px 0px 0px;\n}\n<\/style>\n\t<\/div>\n\n\t\n\n\t<div id=\"col-1408643279\" class=\"col medium-1 small-12 large-4\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_180649985 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n  min-height: 70vh;\n}\n<\/style>\n\t<\/section>\n\t\n\n\t<section class=\"section\" id=\"section_1944435524\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row align-middle align-center\"  id=\"row-1665943098\">\n\n\t<div id=\"col-772083786\" class=\"col medium-11 small-12 large-11\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<p><strong>The main constituent of the sub-urethral wall is fibrous connective tissue. Collagen of types I, III, and VI are the predominant component of this connective tissue<a href=\"https:\/\/urolon.com\/references\/\" target=\"_blank\" rel=\"noopener noreferrer\"><sup>6<\/sup><\/a>. As women with SUI often have a change in their connective tissue metabolism<a href=\"https:\/\/urolon.com\/references\/\" target=\"_blank\" rel=\"noopener noreferrer\"><sup>7-9<\/sup><\/a>, resulting in altered collagen content, stimulation of collagen production has the potential to replace lost collagen in women with SUI, restoring urinary continence by improving outlet resistance.<\/strong><\/p>\n<p>Urolon induces a controlled foreign body response and has the potential to induce neocollagenesis in urethral tissue. Studies have shown that an injection of Urolon induces the formation of collagen type I and III. Collagen type III, over several months, is replaced by the more stable collagen type I. This newly formed collagen scaffold embeds the microspheres in the tissue, limiting the risk of dislocation<a href=\"https:\/\/urolon.com\/references\/\" target=\"_blank\" rel=\"noopener noreferrer\"><sup>10-11<\/sup><\/a>.<\/p>\n<div class=\"row\"  id=\"row-224808775\">\n\n\t<div id=\"col-1759677611\" class=\"col medium-9 small-12 large-9\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_89227141\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"755\" height=\"600\" src=\"https:\/\/www.urolon.com\/wp-content\/uploads\/2022\/02\/GI-004.00_Urolon-Neocollagenesis-Rabbit.jpg\" class=\"attachment-original size-original\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_89227141 {\n  width: 58%;\n}\n<\/style>\n\t<\/div>\n\t\n<p><em>Nicolau PJ, Marijnissen-Hofst\u00e9 J.\u00a0Neocollagenesis after injection of a polycaprolactone based dermal filler in a rabbit.\u00a0<a href=\"https:\/\/www.ejamed.com\/index.php?option=com_content&amp;view=article&amp;id=140:abstract-original-article-pierre-j-nicolau-volume-3-issue-1-2013&amp;catid=9\" target=\"_blank\" rel=\"noopener noreferrer\">Eur J Aesth Med Dermatol, 2013. 3(1): p.19-26<\/a><\/em><\/p>\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1300065579\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"755\" height=\"469\" src=\"https:\/\/www.urolon.com\/wp-content\/uploads\/2022\/02\/Mode-Of-Action_fig2.jpg\" class=\"attachment-original size-original\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_1300065579 {\n  width: 61%;\n}\n<\/style>\n\t<\/div>\n\t\n<p><em>Kim JA, van Abel D. Neocollagenesis in human tissue with a polycaprolactone-based dermal filler.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25260139\" target=\"_blank\" rel=\"noopener noreferrer\">J Cosmet Laser Ther, 2014; early Online: 1-3<\/a><\/em><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-872443586\" class=\"col medium-11 small-12 large-11\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<p>Urolon gives an immediate bulking effect primarily from the CMC gel carrier (70%) with subsequent\u00a0sustained performance\u00a0due to the highly biocompatible PCL microspheres (30%)<sup><a href=\"https:\/\/urolon.com\/references\/\" target=\"_blank\" rel=\"noopener noreferrer\">10-13<\/a><\/sup>. This immediate bulking effect is due to the optimum visco-elasticity of the CMC gel carrier which is key to keeping the PCL microspheres suspended within the gel carrier, and\u00a0<em>in-situ<\/em>, once implanted by injection.\u00a0The CMC gel carrier is gradually resorbed over a period of several weeks to months after treatment.<\/p>\n<div class=\"row\"  id=\"row-1511402878\">\n\n\t<div id=\"col-880522167\" class=\"col medium-7 small-12 large-7\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1604086051\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"755\" height=\"763\" src=\"https:\/\/www.urolon.com\/wp-content\/uploads\/2022\/02\/GI-001.03_Mode-of-action_Fig3.jpg\" class=\"attachment-original size-original\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_1604086051 {\n  width: 72%;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1944435524 {\n  padding-top: 120px;\n  padding-bottom: 120px;\n  background-color: rgb(255,255,255);\n}\n<\/style>\n\t<\/section>\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":1074,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"inline_featured_image":false,"footnotes":""},"class_list":["post-1594","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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